Dr. Manav Pathania

The Pathania group (Dept of Oncology and CRUK Cambridge Centre), led by Dr. Manav Pathania, have a central focus on developing new mouse models for children’s brain tumours, to better understand the interplay between genetic and phenotypic heterogeneity in different brain tumour types. By applying single cell sequencing to identify tumour microenvironmental dependencies and CRISPR screening to test genetic and epigenetic weaknesses in these immune-competent tumour models, they hope in the longer term to pave the way to more targeted, precise treatments that can be tailored to the combination of mutations unique to each tumour. Key areas of interest include identifying and functionally validating the precise type of neural stem or progenitor cells that lie at the root of different brain cancer types, and using mouse models to investigate how brain tumours respond and develop resistance to first-line therapies.

Visit the Pathaia Group’s own webpage here.


Dr. Manav Pathania

Further Information:

Team Members

Manav Pathania (Principal Investigator)

Michael McNicholas (Research Assistant)

Antonella De Cola (Postdoctoral Researcher)

Cameron Bailey Lloyd (Research Assistant)

Amelia Floss (PhD Student)

Publications

Selected Publications:

  • Pathania, M., De Jay, N., Maestro, N., Harutyunyan, A. S., Nitarska, J., Pahlavan, P., . . . Salomoni, P. (2017). H3.3K27M Cooperates with Trp53 Loss and PDGFRA Gain in Mouse Embryonic Neural Progenitor Cells to Induce Invasive High-Grade Gliomas.. Cancer Cell, 32(5), 684-700.e9. doi:10.1016/j.ccell.2017.09.014

Recent Publications:

  • Chen, C. C. L., Deshmukh, S., Jessa, S., Hadjadj, D., Lisi, V., Andrade, A. F., . . . Jabado, N. (2020). Histone H3.3G34-Mutant Interneuron Progenitors Co-opt PDGFRA for Gliomagenesis. Cell. doi:10.1016/j.cell.2020.11.012
  • Finlay, J., Hallou, C., Dewari, P., Pollard, S., Pathania, M., Bulstrode, H., & Rowitch, D. (2019). CHARACTERISING A SOX2+OLIG2+GLIOMA STEM CELL USING CRISPR-ENGINEERED FLUORESCENT REPORTERS IN PRIMARY PATIENT-DERIVED GBM AND DIPG CELLS.. NEURO-ONCOLOGY, 21, 9. doi:10.1093/neuonc/noz167.039
  • Harutyunyan, A. S., Krug, B., Chen, H., Papillon-Cavanagh, S., Zeinieh, M., De Jay, N., . . . Majewski, J. (2019). H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2/me3 and is essential for glioma tumorigenesis.. Nat Commun, 10(1), 1262. doi:10.1038/s41467-019-09140-x
  • Norkett, R., Modi, S., Birsa, N., Atkin, T. A., Ivankovic, D., Pathania, M., . . . Kittler, J. T. (2016). DISC1-dependent Regulation of Mitochondrial Dynamics Controls the Morphogenesis of Complex Neuronal Dendrites.. J Biol Chem, 291(2), 613-629. doi:10.1074/jbc.M115.699447
  • Smith, K. R., Davenport, E. C., Wei, J., Li, X., Pathania, M., Vaccaro, V., . . . Kittler, J. T. (2014). GIT1 and βPIX are essential for GABA(A) receptor synaptic stability and inhibitory neurotransmission.. Cell Rep, 9(1), 298-310. doi:10.1016/j.celrep.2014.08.061
  • Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014). Erratum: The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines (Translational Psychiatry (2014) 4 (e374) DOI: 10.1038/tp.2014.16). Translational Psychiatry, 4. doi:10.1038/tp.2014.36
  • Pathania, M., Davenport, E. C., Muir, J., Sheehan, D. F., López-Doménech, G., & Kittler, J. T. (2014). The autism and schizophrenia associated gene CYFIP1 is critical for the maintenance of dendritic complexity and the stabilization of mature spines.. Transl Psychiatry, 4, e374. doi:10.1038/tp.2014.16
  • Marler, K. J., Suetterlin, P., Dopplapudi, A., Rubikaite, A., Adnan, J., Maiorano, N. A., . . . Drescher, U. (2014). BDNF promotes axon branching of retinal ganglion cells via miRNA-132 and p250GAP.. J Neurosci, 34(3), 969-979. doi:10.1523/JNEUROSCI.1910-13.2014
  • Pathania, M., Torres-Reveron, J., Yan, L., Kimura, T., Lin, T. V., Gordon, V., . . . Bordey, A. (2012). miR-132 enhances dendritic morphogenesis, spine density, synaptic integration, and survival of newborn olfactory bulb neurons.. PLoS One, 7(5), e38174. doi:10.1371/journal.pone.0038174
  • Pathania, M., Yan, L. D., & Bordey, A. (2010). A symphony of signals conducts early and late stages of adult neurogenesis.. Neuropharmacology, 58(6), 865-876. doi:10.1016/j.neuropharm.2010.01.010
  • Smrt, R. D., Szulwach, K. E., Pfeiffer, R. L., Li, X., Guo, W., Pathania, M., . . . Zhao, X. (2010). MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.. Stem Cells, 28(6), 1060-1070. doi:10.1002/stem.431
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Research Collaborations

 

MILNER THERAPEUTICS SYMPOSIUM

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