CAREERS

We are building an experienced and diverse team, where individuality is celebrated, good working culture is prioritised, and team members can learn and progress.  We are seeking to grow our team by finding people who share our vision and want to help us bring discoveries to life.

We’re part of the School of Biological Sciences and the School of Clinical Medicine at the University of Cambridge, located on the Cambridge Biomedical Campus. Our Institute provides a unique working environment, with start-up businesses, academics and pharma companies working side by side across office and laboratory space.

Our current vacancies are listed below. If you have questions about any of our roles, or want to know more about our working culture, we would love to hear from you. Email hr@milner.cam.ac.uk.

Join the Milner Therapeutics Institute Team

Administrative and Personal Assistant (Fixed Term)

The Milner Therapeutics Institute (MTI) is seeking to recruit a motivated Administrative & Personal Assistant to support the MTI Operations team in the smooth running of our growing institute. This varied and interesting role offers opportunities to develop secretarial, administrative & Human Resources (HR) skills.

The Administration & Personal Assistant will join a friendly team based on the Cambridge Biomedical Campus, in an institute that provides a unique working environment, with start-up businesses, academics and pharma companies working side by side across shared office and laboratory space. This is an excellent opportunity to become part of a pioneering, forward-thinking and strategic workforce, with great cultural values.

The role holder will work closely with, and report to, the Human Resources (HR) & Administration Coordinator, to deliver effective and efficient administrative & secretarial support. They will be the first point of contact for queries and greeting visitors and will learn elements of HR to provide support with recruitment and HR-Related administration.

The Administrative & Personal Assistant will assist the Business Operations Manager to ensure smooth running of collaborative research activities, such as Milner Therapeutics board meetings, and will provide PA support to the Executive Director, including diary management, scheduling meetings, booking meeting rooms and ordering refreshments.

Applicants are required to have previous administration experience, including Microsoft Office packages such as word, excel, outlook, and pay excellent attention to detail. Successful candidates will have good customer service, communication, and interpersonal skills, with the confidence to deal appropriately with a wide range of people. They will also have excellent time management and prioritisation skills, the ability to remain calm and professional, and respect confidentiality.

Interviews will be held on Friday 10th or Monday 13th March.

Fixed-term: The funds for this post are available for 3 years in the first instance.

Click the ‘Apply’ button below to register an account with our recruitment system (if you have not already) and apply online.

Informal enquiries can be directed to Saffron Murfitt, HR & Administration Coordinator of the Milner Therapeutics Institute at sgm50@cam.ac.uk (www.milner.cam.ac.uk).

Please quote reference PR35146 on your application and in any correspondence about this vacancy.

The University actively supports equality, diversity and inclusion and encourages applications from all sections of society.

The University has a responsibility to ensure that all employees are eligible to live and work in the UK.

Position further particulars can be downloaded here.

For more information and to apply, please click here.

 

 

Join the Frame Shift Teams

Lead Bioinformatics Scientist, Enhanc3D Genomics

Enhanc3D Genomics is a functional genomics spinout company from the Babraham Institute (Cambridge, UK) leveraging a disruptive technology to profile three-dimensional (3D) genome folding at high resolution. Enhanc3D Genomics is an innovative and dynamic company with diverse and highly engaged staff, who believe in fostering great teamwork to maximise collective skills and experience.

Role Profile

Enhanc3D Genomics are looking for a forward thinking, enthusiastic, highly motivated senior level Lead Bioinformatics Scientist to build out the analysis and interpretation function tackling complex data science across the spectrum of EG’s R&D. Enthusiasm and passion to solve research problems combining data science, machine learning and team synergy are key to this role.

The ideal candidate will have a strong background in a quantitative discipline that will cover domains such as biostatistics, bioinformatics and machine learning. Previous experience and domain knowledge in target or biomarker discovery would be highly advantageous to function in this role. Further, experience in team management and reporting to executive management would make for a strong candidate.

You should be an organised professional with exceptional interpersonal and communication skills, enabling you tosuccessfully operate in a business environment where confidentiality and discretion are paramount.

Key Accountabilities

 

  • Lead on bioinformatics, biostatistics and visualisation programmes
  • Develop innovative strategies for EG’s target discovery / biomarker discovery programmes, including assessment, benchmarking and theoretical development of EG’s statistical algorithms and methodology, as well as contribute to efficient computational implementations.
  • Contribute and oversee scientific design both for technology development and biological insight end-points
  • Produce professional reporting outputs for internal research and external collaborations.
  • Work across teams and proactively engage in knowledge sharing and peer support, including training
  • Line management

To download further particulars for this role, please click here.

To apply for this position, please submit your CV and a covering letter to hr@enhanc3dgenomics.com

Visit the Enhanc3D website at http://enhanc3dgenomics.com

 

Senior Scientist, Enhanc3D Genomics

Enhanc3D Genomics Babraham Institute disruptive technology to profile three-dimensional (3D) genome folding at high resolution. Understanding DNA organisation and long-distance interactions allows to link gene enhancers and non-coding genetic variants to their target genes and holds promise to unlock disease-related genetics for therapeutic discovery.

Role Profile

Enhanc3D Genomics is an innovative and dynamic company with diverse and highly engaged staff. We believe in fostering great teamwork to maximise our collective skills and experience. We are passionate about realising the power of 3D genomics by developing new cutting-edge technologies for therapeutic discoveries.

We are looking for a forward-thinking, enthusiastic, highly motivated Senior Scientist to join the technology team currently developing cutting-edge technologies to assay 3D genomic conformations. Enthusiasm and passion to deliver a high-quality finished product are keys to this role. The ideal candidate will have expertise in molecular and cell biology, next- generation sequencing, epigenetics and data analysis as well as a strong desire to work in a fast-paced and stimulating environment.

You will be involved in collaborative projects with academic and commercial research groups to deliver high-quality data reports and develop technologies and ideas, contributing to our IP portfolio. You will be flexible and keen to support the technology development while championing quality in all aspects of your work.

You will be an organised and competent professional with exceptional interpersonal and communication skills, enabling you to successfully operate in a business environment where confidentiality and discretion are of paramount importance.

       Key Accountabilities 

  • Apply common and tailored methods designed to maximise viability of a variety of cell
  • Perform or oversee FACS sorting DNA/RNA quantification and QC using different methods (fluorometry, spectrophotometry, electrophoresis, size, etc.)
  • Design experiments
  • Develop Hi-C library generation protocols
  • Develop sequencing protocols
  • Develop sequencing strategies
  • Help build and steer the development of ‘small’ prototype tools of bench scientists to access and visualise project data exploring non-traditional approaches to bring big data together in biologically meaningful ways
  • Develop QC standards and introduce quality metrics
  • Troubleshoot all aspect of the in-house pipeline
  • Liaise with, and support projects with, academic collaborators and industrial partners
  • In collaboration with the data science team build a ‘tissue atlas’ database for research and development purposes
  • Write SOPs, risk assessments, and work instructions
  • Produce reports for internal research and external collaborations
  • Work across departments and proactively engage in knowledge sharing and peer support, including training of laboratory technicians and scientists
  • Champion H&S and quality compliance within the team
  • Discuss scientific findings and provide written and verbal project progress reports and updates
  • Flexibility to perform other duties which may be required

    Required Skills and Abilities
 
  • Ability to design experiments, problem solve, troubleshoot and assess technology performance
  • Ability to work independently and within a group but be able to recognise when to seek help
  • Excellent oral and written communication skills
  • Excellent organisational and record keeping skills
  • Able to collaborate with industry and academia
  • Good understanding of Laboratory Health and Safety


    Qualification and Experience

  • PhD and postdoctoral research, or equivalent experience with formal training and proven expertise, in a biology-based discipline such as genetics, molecular biology or biochemistry
  • Demonstrable expertise in a wide range of molecular biology techniques including DNA extraction, quantification, amplification, modification, purification, ‘omics’ techniques
  • Experience with Next-Generation Sequencing platforms and library preparation
  • Demonstratable experience of innovation and development of cutting-edge technologies
  • Proven experience of working in a fast-paced research-driven commercial environment or in collaboration with industry
  • Experience using cell culture techniques
  • Preferable experience with and understanding of Hi-C, targeted capture, HiChIP, RNASeq, ATAC-Seq
  • Preferable experience with gene editing methods such as CRISPR/Cas9 To apply for this position,
 

To download further particulars for this role, please click here.

To apply for this position, please submit your CV and a covering letter to hr@enhanc3dgenomics.com

Visit the Enhanc3D website at http://enhanc3dgenomics.com

 

Scientist, Enhanc3D Genomics

Enhanc3D Genomics is a functional genomics spinout company from the Babraham Institute (Cambridge, UK) leveraging a disruptive technology to profile three-dimensional (3D) genome folding at high resolution. Enhanc3D Genomics is an innovative and dynamic company with diverse and highly engaged staff, who believe in fostering great teamwork to maximise collective skills and experience.

Role Profile

Enhanc3D Genomics is an innovative and dynamic company with diverse and highly engaged staff. We believe in fostering great teamwork to maximise our collective skills and experience. We are passionate about realising the power of 3D genomics by developing new cutting-edge technologies for therapeutic discoveries.

We are looking for a forward-thinking, enthusiastic, highly motivated, and technically skilled Scientist to join the technology team currently developing cutting-edge technologies to assay 3D genomic conformations. Enthusiasm and passion to deliver a high-quality finished product are keys to this role. The ideal candidate will have expertise in molecular and cell biology, next-generation sequencing, epigenetics as well as a strong desire to work in a fast-paced and stimulating environment.

You will be involved in collaborative projects with academic and commercial research groups to deliver high-quality data, contributing to our IP portfolio. You will be flexible and keen to support the technology development while championing quality in all aspects of your work.

You will be an organised and competent professional with exceptional interpersonal and communication skills, enabling you to successfully operate in a business environment where confidentiality and discretion are of paramount importance.

Key Accountabilities

  • Perform DNA extraction, DNA/RNA quantification and QC using different methods (fluorometry, spectrophotometry, electrophoresis, size, etc.)
  • Hi-C library generation
  • RNA/DNA NGS library preparation
  • Culture cell lines to keep sufficient supply for R&D projects
  • Assist in experiments design
  • Understand company objectives and help in coordination of the day-to-day laboratory activities. Report on issues where appropriate. Share good practice.
  • Help to build and steer the development of ‘small’ prototype tools for bench scientists to access and visualise project data exploring non-traditional approaches to bring big data together in biologically meaningful ways
  • Help to troubleshoot all aspect of the in-house pipeline
  • Liaise with, and support projects with, academic collaborators and industrial partners
  • In collaboration with the data science team build a ‘tissue atlas’ database for research and development purposes
  • Help to draft, review, and optimise SOPs and associated Risk Assessments to ensure maximum efficacy.
  • Trial new reagents/equipment where applicable
  • Monitor laboratory resources, re-ordering where necessary to ensure stock levels are maintained
  • Samples and libraries submission for processing and sequencing, to use a database to track the progress of samples throughout the whole process
  • Provide technical advice and guidance to less experienced team members where applicable
  • Champion H&S and quality compliance within the team
  • Flexibility to perform other duties which may be required

Required Skills and Abilities

  • Ability to test and implement new approaches and techniques
  • Ability to work independently and within a group but be able to recognise when to seek help
  • Excellent oral and written communication skills and ability to keep good records
  • Able to collaborate with industry and academia
  • Good understanding of Laboratory Health and Safety

Qualification and Experience

  • Biological degree with relevant laboratory experience
  • Experience in a wide range of molecular biology techniques including DNA/RNA extraction, quantification, amplification, purification
  • Experience with Next-Generation Sequencing platforms and library preparation
  • Preferable experience with and understanding of Hi-C, targeted capture, HiChIP, RNASeq, ATAC-Seq
  • Experience using cell culture techniques
  • Proven experience of working in a fast-paced research-driven commercial environment or in collaboration with industry

 

To download further particulars for this role, please click here.

To apply for this position, please submit your CV and a covering letter to Ann Rone at hr@enhanc3dgenomics.com

Visit the Enhanc3D website at http://enhanc3dgenomics.com

 

Cell Biology Scientist, Cosyne Therapeutics

CoSyne Therapeutics is a computational drug discovery company that uses genetic and computational systems to develop next-generation medicines. The company’s first goal is to create a new class of drugs to treat the deadliest form of human brain cancer: Glioblastoma Multiforme. Our novel platform allows us to identify vulnerabilities in cells that no other company or academic institution has done before.

CoSyne recently closed a substantial seed funding round from industry-leading investors and the company is looking to grow the functional genomics and cell biology team. The scientist will be a key member of the target discovery and functional genomics team and will help develop novel cell biology assays and CRISPR screens. Together with the computational and AI teams, the target discovery team is creating a suite of cell biology tools and employing a diverse range of target discovery approaches.

The successful candidate will join an enthusiastic and collaborative team based at the Milner Therapeutics Institute in Cambridge, an exciting multidisciplinary scientific environment on the Cambridge Biomedical Campus. As part of a well-funded start-up, the role holder will have all the resources necessary to make the science work, will have excellent opportunities to grow their skills, and will work with a truly fantastic team to develop therapeutics to treat currently incurable diseases.

Main Activities will Involve

  • Culturing and maintenance of cell lines, including neuroepithelial stem cells (NSCs) and neurosphere cultures.
  • Helping to design and perform genomic screens and target discovery – this includes CRISPR technologies, siRNA and pooled screen approaches.
  • Work within the functional genomics team to optimise and troubleshoot target validation approaches using a range of molecular and cell biology approaches.
  • Take the lead on key projects within the team, this will include working with computational scientists and AI specialists to iterate experimental approaches.
  • Keep up to date with novel cell biology and target discovery approaches and bring these new methodologies into CoSyne

Requirements

  • At least 4 years’ experience in a laboratory environment.
  • Knowledge and experience of CRISPR or shRNA methodologies.
  • Experience in developing and optimising novel cell and molecular biology approaches.
  • Extensive experience in cell culture ideally with a background in cancer biology and/or experience with NSCs.
  • A creative, curious and inventive approach to work combined with scientific rigour.
  • Enjoy understanding how pieces fit together in the larger scientific and competitive landscape
  • Be Kind.
  • This role would suit someone finishing their PhD, or a postdoc wanting to move into biotech or a scientist with biotech experience wanting to make the next step in their career.

Benefits

  • As an early employee of the company you will be involved in every aspect of the business and help set the direction/culture as we grow.
  • The opportunity to work at the cutting edge of functional genomics and drug discovery.
  • We are building a highly multidisciplinary team and are focused on breaking down silos between the lab and computational biology.
  • Membership to CoSyne’s Equity scheme.
  • All the perks of a start-up – highly competitive salaries, great IT, team dinners/socials, flexible working, flat structure, and a dynamic work environment.

Our mission is to help patients with devastating diseases. Everything else is secondary.

We interview on a rolling basis and so this role will be filled when we find the right candidate

For more information on this position please click here

To apply please click here.