CAREERS

We are recruiting a Bioinformatician with interest in functional genomics to join the FGSL team. You will be applying your analytical skills to design experiments, develop new computational tools, analyse results, decipher patterns and generate new biological insights. You will have the opportunity to contribute to the collective lab portfolio in various disease areas with an umet need for therapies. This is a collaborative role where you will work with scientists from MTI, AstraZeneca and academics and small enterprises from across the UK. As a key member of the new team, you will have the opportunity to provide significant input in determining the direction of the lab.

The MTI is a buoyant, vibrant and fast-paced environment and is ideal for those who thrive in the face of change. This role would suit highly motivated individuals with desire to acquire skills in new areas such as multi-modality screens, laboratory automation and bioinformatic analysis. You will leverage on your existing knowledge and expertise in a particular biological field and have the opportunity to contribute to a wide range of disease areas via implementing high-throughput CRISPR screening. We welcome applications from recent PhD graduates that are enthusiastic to work as part of a dynamic team at the interface between academia and industry. We offer an engaging and supportive environment that fosters professional growth and career development.

This advert will close on 18 August.

For informal enquiries about this role please contact Chun Hao Wong, FGSL lead, wc389@cam.ac.uk, quoting reference PR42296.

To find out more and to apply, click here.

Frame Shift company Shift Bioscience is hiring at the Frame Shift – City Centre hub.

Join Shift, where you’ll become an integral member of a high-performing and fast-moving team whose mission is to deliver the first drugs for safe cellular rejuvenation, addressing chronic diseases and extending healthy human lifespan.

As a Validation Scientist at Shift, you’ll deliver rejuvenating gene combinations and small molecules to aged human cells. You’ll work alongside our Head of Target Validation to provide valuable evidence about the safety, efficacy and generalisability of our rejuvenation candidates, to ensure only the best make it through to preclinical testing. You will also have the opportunity to contribute to the design and running of our discovery platform. You will report directly to Brendan Swain, CSO.

What will you do?

●      Test promising interventions to ensure our high-throughput readouts are well-calibrated.

●      Characterise our best rejuvenation candidates using multi-omics and functional assays in several clinically relevant cell types.

For more information and to apply, click here.

Frame Shift company Shift Bioscience is hiring at the Frame Shift – City Centre hub.

Join Shift, where you’ll become an integral member of a high-performing and fast-moving team whose mission is to deliver the first drugs for safe cellular rejuvenation, addressing chronic diseases and extending healthy human lifespan.

As part of the Research and Development Department at Shift, you’ll work alongside our Head of R&D to build the in vitro tools driving the discovery of safe rejuvenation interventions, and then understand their mechanisms. You will also work closely with our Platform and Target Validation teams to identify areas that require innovative approaches to maximise their potential. You will report directly to Brendan Swain, CSO.

What will you do?

●      Develop state-of-the-art in vitro methods to accelerate our discovery of safe rejuvenation genes

●      Explore the effects and mechanisms of our promising safe rejuvenation candidates

For more information and to apply, click here.

At clock.bio, we believe that ageing, while natural, is not inevitable. As the shared risk factor of the deadliest diseases, the process of ageing forms the core of our focus. Our mission is to develop novel therapeutic pathways for treating age-related diseases, using the regenerative power of pluripotent stem cells.

As a fast-paced biotech startup, we are looking for a Lead Computational Biologist / Bioinformatician who shares our vision of a future where health is our default state and is excited about the opportunity to make a significant impact on our mission.

Role

The Lead Computational Biologist / Bioinformatician will play a pivotal role as the first internal full-time bioinformatics role, inheriting existing infrastructure and collaborating with ongoing bioinformatic contractors. The role will primarily be research-focused, including hands-on analysis of all omic data produced by clock.bio, and contextualising it with respect to datasets from external studies.

In addition to research, the role will also include data management duties and collaboration with teams in other locations and time zones. Given the startup nature of clock.bio, there will be opportunities for the individual to wear multiple hats and contribute to various aspects of the business.

Responsibilities

• The candidate will lead the bioinformatic endeavours of clock.bio, acting as the “in house” bioinformatic thought leader.
• Analyse high dimension NGS data including both bulk and single-cell RNA-seq and ATAC-seq data from pooled CRISPR screens.
• Provide input to the computational biology strategy and take responsibility for its day-to-day execution working with cross-functional partners and leadership teams.
• Build data collection, data annotation, and data cleaning workflows, and compile datasets for specific projects and downstream in-depth data analyses.
• Assess new model systems of ageing and rejuvenation and provide insights into their potential application in our mission.
• Work with bench scientists by guiding experimental workflows and quantitative measurement to ensure statistical rigour and help build data visualisations.

For more information and to apply, click here.