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X-WR-CALNAME:Webinar: Harnessing the power of whole genome arrayed scree
 ning to discover new mechanisms and targets in rare genetic conditions
X-WR-CALDESC:The Milner Therapeutics Institute
X-WR-TIMEZONE:Europe/London
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DTSTART:20240409T220000
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SUMMARY:Webinar: Harnessing the power of whole genome arrayed screening 
 to discover new mechanisms and targets in rare genetic conditions
DESCRIPTION:&#x1f5d3\;&#xfe0f\; 9th October\n&#x23f0\; 10:00am\n&#x1f4cd
 \; Online (Zoom)\n\nJoin us for this webinar presented by the MRC-AstraZ
 eneca-University of Cambridge Joint Functional Genomics Screening Labora
 tory.\n\nSpeaker: Dr Delphine Larrieu\, Altos Labs\n\nAbstract: Progeria
  syndromes are very rare\, incurable premature aging conditions recapitu
 lating most aging features. They are caused by mutations in nuclear enve
 lope proteins\, who play major roles in maintaining the structure of the
  nucleus\, as well as the organisation of the chromatin. As a result of 
 these mutations\, patient-derived cells display a dramatic loss of nucle
 ar envelope integrity\, characterised by nuclear shape distortion\, nucl
 ear envelope ruptures and abnormal localisation of nuclear envelope prot
 eins. With the goal of identifying new players that could restore nuclea
 r envelope integrity and cell health in Progeria patient cells\, we desi
 gned a whole genome screen\, looking for genes that could reverse multip
 le nuclear envelope associated phenotypes at once. These phenotypes can 
 only be assessed by microscopy on adherent cells\, preventing the use of
  pooled\, flow cytometry-based screening strategies. We therefore implem
 ented a whole genome\, CRISPR arrayed screen that proved to be a powerfu
 l approach for identifying new genes enhancing cellular resilience in pr
 emature aging and uncover novel biology behind progeria-associated cellu
 lar dysfunction.\n\nClick here to register &gt\;&gt\;
URL;VALUE=URI:https://www.milner.cam.ac.uk/events/webinar-harnessing-the
 -power-of-whole-genome-arrayed-screening-to-discover-new-mechanisms-and-
 targets-in-rare-genetic-conditions/
UID:urn:uuid:1f9748e3-74a9-4f33-8dae-bd2b8b568e38
STATUS:CONFIRMED
ORGANIZER:
DTSTAMP:20260604T105929Z
DTSTART;TZID=Europe/London:20241009T100000
DTEND;TZID=Europe/London:20241009T110000
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