BEGIN:VCALENDAR
METHOD:PUBLISH
VERSION:2.0
CALSCALE:GREGORIAN
PRODID:-//NONSGML WPForms//NONSGML Sugar Calendar Feeds v3.11.1//EN
X-WR-CALNAME:Milner Institute Special Seminar - Professor Soojin Ryu
X-WR-CALDESC:The Milner Therapeutics Institute
X-WR-TIMEZONE:Europe/London
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:20230326T010000
TZNAME:BST
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VTIMEZONE
TZID:Europe/London
BEGIN:DAYLIGHT
TZOFFSETFROM:+0000
TZOFFSETTO:+0100
DTSTART:20230326T010000
TZNAME:BST
END:DAYLIGHT
END:VTIMEZONE
BEGIN:VEVENT
SUMMARY:Milner Institute Special Seminar - Professor Soojin Ryu
DESCRIPTION:Join us on Monday\, 17th July for a special seminar. No reg
 istration is necessary and address details can be found below.\n\nSpeake
 r\nProfessor Soojin Ryu\, Living Systems Institute\, University of Exete
 r\nTopic\n"A novel zebrafish model to identify molecular signatures of s
 tress-induced maladaptation"\nAbstract\nChronic or severe stress exposur
 e during development is a strong risk factor for developing neuropsychia
 tric diseases in humans. One proposed mechanism involves the priming of 
 stress-sensitive gene networks through early life exposure to glucocorti
 coids (GCs)\, which can modify stress responses later in life. However\,
  the comprehensive understanding of brain-wide molecular alterations ind
 uced by GC priming remains limited. We developed and utilized a novel op
 togenetic zebrafish model to elevate endogenous GC levels during develop
 ment and identified the transcriptomic changes in the brain across the l
 ife course. When developmental GC-exposed fish were exposed to acute str
 ess in adulthood\, they exhibited highly exaggerated endocrinal and tran
 scriptional changes. These changes included gene sets associated with ax
 on development\, neuronal signaling\, and epigenetic modulators. Remarka
 bly\, the altered gene sets were enriched with risk genes associated wit
 h human psychiatric disorders. This model may be useful for identificati
 on of molecular targets relevant for stress-induced maladaptation includ
 ing neuropsychiatric disease susceptibility.\nA Short Biography\n\nBA Ha
 rvard University\nPhD in Molecular and Cell Biology\, University of Cali
 fornia\, Berkely\nHuman Frontiers Long Term Postdoc Fellow – Universit
 y of Freiburg\, Germany\n2009-2015: Max Planck Research Group Leader –
  Max Planck Institute for Medical Research\, Heidelberg\, Germany\n2015-
 2019: Associate Professor – University of Mainz\, Germany\nSince 2020:
  Full Professor and Assistant Director – Living Systems Institute\, Un
 iversity of Exeter\nJeffery Cheah Biomedical Centre Lecture Theatre\nPud
 dicombe Way CB2 0AW\n&nbsp\;
URL;VALUE=URI:https://www.milner.cam.ac.uk/events/milner-institute-speci
 al-seminar-professor-soojin-ryu/
UID:urn:uuid:1b7bdf91-7487-4994-bc9b-3b319b3f08ff
STATUS:CONFIRMED
ORGANIZER:
DTSTAMP:20260604T105238Z
DTSTART;TZID=Europe/London:20230710T000000
DTEND;TZID=Europe/London:20230710T170000
END:VEVENT
END:VCALENDAR