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X-WR-CALNAME:FGSL Webinar: Overexpression of LIGHT on cancer cells facil
 itates T-cell cross-priming
X-WR-CALDESC:The Milner Therapeutics Institute
X-WR-TIMEZONE:Europe/London
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DTSTART:20250415T230000
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SUMMARY:FGSL Webinar: Overexpression of LIGHT on cancer cells facilitate
 s T-cell cross-priming
DESCRIPTION:&#x1f5d3\;&#xfe0f\; 15 October\n&#x23f0\; 11:00am-12:00pm\
 n&#x1f4cd\; Online\n\nJoin the Functional Genomics Screening Laboratory
  (FGSL) team as we welcome Dr Lorena Boquete Vilariño for this special 
 webinar.\n\nSpeaker: Dr Lorena Boquete Vilariño\, Centro de Fabricació
 n de Terapias Avanzadas de Galicia\, Galaria EPSS SA\n\nAbstract: Dendri
 tic cells (DCs) are key to initiate anti-tumour immune responses\, but t
 heir function is commonly disrupted in cancer. We performed a genome-wid
 e arrayed CRISPR-Cas9 screen in a cancer cell - DC co-culture system and
  uncovered genes which upon knockout in cancer cells could lead to activ
 ation in DCs. Using transcriptomics together with binding partner analys
 is we discovered that overexpression of a single protein (LIGHT) in canc
 er cells could activate dendritic cells and promote T-cell activation in
  a cross-priming assay.\n\nRegister at: cam-ac-uk.zoom.us/meeting/regist
 er/WnKnPejJQfyoB4vYcVobdw#/registration
URL;VALUE=URI:https://www.milner.cam.ac.uk/events/fgsl-webinar-overexpre
 ssion-of-light-on-cancer-cells-facilitates-t-cell-cross-priming/
UID:urn:uuid:b4e873d9-7dd1-44ce-9954-58cd5a4ed46f
STATUS:CONFIRMED
ORGANIZER:
DTSTAMP:20260604T105351Z
DTSTART;TZID=Europe/London:20251015T110000
DTEND;TZID=Europe/London:20251015T120000
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