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X-WR-CALNAME:FGSL Webinar: Genetic modifier screen in human neurons reve
 als interaction between SARM1 and rare neuropathies 
X-WR-CALDESC:The Milner Therapeutics Institute
X-WR-TIMEZONE:Europe/London
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SUMMARY:FGSL Webinar: Genetic modifier screen in human neurons reveals i
 nteraction between SARM1 and rare neuropathies 
DESCRIPTION:&#x1f5d3\;&#xfe0f\; 11 April\n&#x23f0\; 11:00am-12:00pm\n&
 #x1f4cd\; Online\n\nJoin the Functional Genomics Screening Laboratory (
 FGSL) team as we welcome Dr Andrea Elser for this special webinar.\n\nSp
 eaker:\nDr. Andrea Elser\, Applied Stem Cell Sciences Team\, Centre for 
 Genomics Research\, Discovery Sciences\, BioPharmaceuticals R&amp\;D\, A
 straZeneca\, Gothenburg\, Sweden.\n\nAbstract:\nRare neuropathies\, chem
 otherapy-induced neurodegeneration and SARM1 activity share common chara
 cteristics. NAD-consuming enzyme SARM1 plays a central role in programme
 d axon death and its loss-of-function has been shown to be protective in
  subtypes of Charcot-Marie-Tooth disease and Hereditary Spastic Parapleg
 ia. These diseases are characterised by neurite degeneration and mitocho
 ndrial defects and currently lack effective therapies. SARM1 inhibitors 
 may provide a much-needed disease-modifying opportunity for certain mech
 anistic subtypes of rare neurological disorders. To evaluate if SARM1 lo
 ss-of-function can protect against neurite degeneration linked to rare n
 europathies\, we performed arrayed phenotypic CRISPR-Knock-out (KO) scre
 ens in wildtype and SARM1-KO human iPSC-derived neurons\, focusing on 60
  disease-associated genes. In this webinar\, we will present in vitro mo
 del validation data and how the genetic screen was used to identify rare
  neuropathies where SARM1 inhibition can be neuroprotective.\n\nRegister
  at: cam-ac-uk.zoom.us/meeting/register/1pZA1ZYPQmGL7kA-TP2UZQ#/registra
 tion
URL;VALUE=URI:https://www.milner.cam.ac.uk/events/fgsl-webinar-genetic-m
 odifier-screen-in-human-neurons-reveals-interaction-between-sarm1-and-ra
 re-neuropathies/
UID:urn:uuid:141899ed-89d1-448c-91b8-fc80d7095c39
STATUS:CONFIRMED
ORGANIZER:
DTSTAMP:20260604T105358Z
DTSTART;TZID=Europe/London:20250411T110000
DTEND;TZID=Europe/London:20250411T120000
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